Brain histamine H1receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with11C-doxepin
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چکیده
منابع مشابه
Blood levels and DA transporter occupancy of orally administered methylphenidate in juvenile rhesus monkeys measured by high resolution PET.
KRISTIN M. WILCOX, YUN ZHOU, DEAN F. WONG, MOHAB ALEXANDER, ARMAN RAHMIM, JOHN HILTON, AND MICHAEL R. WEED Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 Department of Radiology, Johns Hopkins University School of Medicine, Baltimore 21205 Department of Environmental Health Sciences, Johns Hopkins University School of Pub...
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Drugs with antihistamine action are the most commonly prescribed medication in daily dermatologic practice, both to adults and children. This article addresses new concepts of the role of histamine receptors (H1 receptors) and discusses the anti-inflammatory effects of these drugs. Second generation antihistamines differs from first generation because of their high specificity and affinity for ...
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Second-generation antihistamines are widely prescribed for the control of symptoms of allergic inflammation such as itchy hives, coryza, and itchy eyes. In rare circumstances, these drugs might provoke allergic inflammation. Hypersensitivity to bepotastine besilate, a second-generation antihistamine has never been reported. A 17-year-old schoolgirl, whose paroxysmal itchy hives had been control...
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Several lines of evidence suggest that brain histamine may be involved in the central control of food intake. The effect of histamine on feeding is mediated through three kinds of receptors (H1, H2, and H3). The present study was designed to investigate the effect of intracerebroventricular injection of histamine, promethazine (H1 antagonist) and ranitidine (H2 antagonist) on food intake of fre...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2008
ISSN: 0306-5251,1365-2125
DOI: 10.1111/j.1365-2125.2008.03143.x